In an effort to
sell more drugs, medical ghost writing is the practice of paying authors
to write favorable drug reports for pharmaceutical companies. The truth
be known, medical ghost writing leads to mass deception among medical
doctors and declining health among prescription drug users. Worse,
it can also lead to needless deaths.
To better illustrate
the negative impacts of medical ghost writing we look to Dr. M. Michael
Wolfe. As a medical expert, editors of the Journalof the American Medical
Association (JAMA) sent him an unpublished drug review on the arthritis
medication Celebrex to evaluate. At first glance, he was impressed
by what he read. It appeared that after six months of a company-sponsored
study involving more than 8,000 patients, the drug was associated with
lower rates of stomach and intestinal ulcers than two older arthritis
medicines, diclofenac and ibuprofen. Feeling confident that the drug
was safe, Dr. Wolfe and colleagues wrote a favorable editorial about
Celebrex to accompany the newly released findings in JAMA. Consequently,
millions of M.D.'s began prescribing the now commonly used Celebrex.
As time passed,
it was later learned that like many medical doctors of today, Dr. Wolf
was a victim of ghost writing. As fate would have it, Dr. Wolfe later
came across the complete data from the same study as a member of the
Food and Drug Administration's arthritis advisory committee. Numerous
discrepancies were seen between the initial report and the newly found
raw data. Most notably, Pharmacia, the manufacturers of Celebrex, made
it appear as if the study lasted only 6 months. In reality, the study
of Celebrex lasted a year. During the last half of the year (which
was unreported) almost all of the ulcer complications that occurred
during the study were in Celebrex users.
When all of the
data were considered, Dr. Wolfe stated that most of Celebrex's apparent
safety advantages disappeared. Unfortunately, JAMA had already released
the previously written findings that were derived from the fabricated
report along with Dr. Wolf's favorable editorial. In an effort to discover
why the initial report did not illustrate the entire findings of the
study, Dr. Wolfe found that the study's 16 authors included faculty
members of eight medical schools. All authors were either employees
of Pharmacia or paid consultants of the company.
The Blatant lies
and disregard for patients health get's worse. Between 1990 and 1997
all clinical trials performed on non-steroidal anti-inflammatory drugs
(NSAIDS) such as Alleve, aspirin, Motrin, Ibuprofen, Bayer, celecoxib
--Celebrex®, diclofenac -- Voltaren®, etodolac --Lodine®, fenoprofen
-- Nalfon®, indomethacin -- Indocin®, ketoprofen - Orudis®, Oruvail®,
ketoralac --Toradol®, oxaprozin -- Daypro®, nabumetone -- Relafen®,
sulindac -- Clinoril®, tolmetin -- Tolectin®, rofecoxib -- Vioxx® were
sponsored by the drug manufacturer! The result was that 100% of the
studies showed the sponsored drug to have equal or superior efficacy
when compared to other drugs.
The fallacies
behind medical ghost writing of NSAIDS are quickly exposed via increasing
body counts among users. Despite the fabricated studies showing NSAIDS
to be safe, real-life observations show that approximately 107,000
patients are hospitalized every year for non steroidal anti-inflammatory
drug-related gastrointestinal complications. Moreover, at least 16,500
NSAID-related deaths occur each year among arthritis patients. This
figure, as reported by Dr. Gurkirpal Singh, is comparable to the number
of deaths from the acquired immunodeficiency syndrome [AIDS] and shows
that NSAIDS contribute to as many deaths as multiple myeloma, asthma,
and cervical cancer combined!
Although outrageously
high, the aforementioned statistics do not account for over-the-counter
use of NSAIDS. Thus, we can be confident that there are considerably
more deaths caused by the use of NSAIDS that go unreported. And because
few medical doctors are unaware of these statistics, NSAIDS can rightfully
be considered a silent killer, especially when "experts" are
paid to write favorable reviews and drug manufacturers carry out their
own clinical studies.
Not being aware
of this silent killer, millions of American's are consuming NSAIDS
on a daily basis on the false hypothesis that they will successfully
enhance their longevity. This will go down in the history books as
one of America's deadliest health myths. How many people do you know
who take an aspirin a day in an attempt to lower their risk of heart
disease? What about Celebrex?
Ghost writing
is a common, yet rarely mentioned practice among the drug industry.
Very few professionals and patients are able to get the real-scoop
on the drug they are either prescribing or consuming. This further
illustrates the importance of seeking information about natural alternatives
which are not only effective but have killed less people than bee stings.
References
Okie, Susan.
Washington Post, August 5, 2001; Page A11
Ivan Oransky
and Jeanne Lenzer. Ties to drug manufacturers deform medical reviews.
USA Today. McLean, Va.:Aug1, 2002. pg A. 11
Singh Gurkirpal,
MD, "Recent Considerations in Nonsteroidal Anti-Inflammatory Drug
Gastropathy", The American Journal of Medicine, July 27, 1998,
p. 31S
Verrico MM,
Weber RJ, McKaveney TP, Ansani NT, Towers AL. Adverse Drug Events Involving
COX-2 Inhibitors. Ann Pharmacother. 2003 Sep;37(9):1203-13.
Author Profile
Shane Ellison holds a Master's degree in organic chemistry and has
first-hand industry experience with drug research, design and synthesis.
His web sites are www.health-fx.net and www.healthmyths.net.
Visit them for jaw-dropping facts about health, fitness and natural
medicine!